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Download Acromegaly: A Century of Scientific and Clinical Progress by Dr. Martin Pierre Marie Granier (auth.), Richard J. Robbins PDF

By Dr. Martin Pierre Marie Granier (auth.), Richard J. Robbins M.D., Shlomo Melmed M.D. (eds.)

The manuscripts during this quantity have been contributed via the audio system invited to the Acromegaly Centennial Symposium held in San Francisco, California in July 1986. The assembly used to be equipped to commemorate the outline of acromegaly through the French health professional Pierre Marie, in 1886. The participants of the medical Committee spent many hours aiding us in making sure a great assembly. The help of Serono Symposia, united states in all stages of the making plans and execution of the assembly was once truly preferred and used to be hugely expert. distinctive reputation roust be prolonged to Professor Roger Guillemin of the Salk Institute, whosp curiosity in scientific background led him to dedicate loads of time and private price in acquiring information regarding the lifetime of Pierre Marie. Dr. GuilIemin's presentation at the existence and instances of Marie was once a rare evaluate of the cultural, social, and clinical backgrounds within which Marie got here to explain the disorder, acromegaly. Dr. Guillemin' s findings, that have been provided on the major dinner party in a most suitable audiovisual presentation, have been sincerely the spotlight of the assembly and should lengthy be remembered through the attendees. We have been additionally venerated by means of the presence of Dr. Martine Pierre Marie Granier, the great-granddaughter of Pierre Harie. In her handle on the dinner party, Dr. Granier supplied a number of pleasant and intimate vignettes referring to Pierre Marie, utilizing previous relations files and pictures. The clinical Committee needs to increase its gratitude to Dr. Granier for including immeasurably to the old surroundings of the meeting.

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J Clin Endocrinol Metab 1985; 61:666. 34. Froesch ER, Schmidt CH, Schwander J, Zapf J. Actions of insulin-like growth factors. Annu Rev Physiol 1985; 47:443. 35. Berelowitz M, Szabo M, Frohman LA, Firestone S, Chu L, Hintz RL. Somatomedin-C mediates growth hormone negative feedback by effects on both the hypothalamus and the pituitary. Science 1982; 212:1279. 36. Brazeau P, Guillemin R, Ling N, Van Wyk JJ, Humbel R. Inhibition by somatomedins of growth hormone secretion stimulated by hypothalamiC growth hormone releasing factor (somatocrinin, GRF) on the synthetic peptide hpGRF.

23 20. Ishibashi M, Yamaji T. Effects of hypophysiotropic factors on growth hormone and prolactin secretion from somatotroph adenomas in culture. J Clin Endocrinol Metab 1985; 60:985. 21. Ceda GP, Hoffman AR, Silverberg GD, Wilson DM, Rosenfeld RG. Regulation of growth hormone release from cultured human pituitary adenomas by somatomedins and insulin. J Clin Endocrinol Metab 1985; 60:1204. 22. Said SI, Porter JC. Vasoactive intestinal polypeptide; release into hypophyseal portal blood. Life Sci 1979; 24:227.

Table 4. Proportions (as percent) of plasma monomeric GH forms (mean ± SEM) in normal subjects and acromegalic patients. GH 22K GH 20K Acidic GH Normals (n = 22) (various secretory stimuli) 77. 0±1. 9 Acromegaly (n = 8) 72. 6±1. 4 39 To test this hypothesis, I have calculated the theoretical percentage of complexed GH, based on the saturation curve for the binding protein (14), for the plasma samples included in Gorden's paper, taking into account the endogenous GH level in each plasma. I then correlated the calculated (predicted) percentage of protein-bound GH with the percentage of big and big-big (pre-big) GH reported by Gorden for each sample.

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