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Download Advances in Biochemical Engineering & Biotechnology, Volume by Urs von Stockar (Editor), Luuk van der Wielen (Editor) PDF

By Urs von Stockar (Editor), Luuk van der Wielen (Editor)

Technique integration has been essentially the most lively study fields in Biochemical Engineering over the past decade and it'll remain so if bioprocessing is to turn into extra rational, effective and effective. This quantity outlines what has been completed in recent times. Written through specialists who've made vital contributions to the ecu technological know-how, origin application on technique Integration in Biochemical Engineering, the quantity specializes in the growth made and the key possibilities, and likewise at the boundaries and the demanding situations in bioprocess integration that lie forward. the concept that of bioprocess integration is taken care of at a number of degrees, together with integration on the molecular, organic, bioreactor and plant degrees, but additionally accounting for the combination of separation and mass move operations and biology, fluid dynamics and body structure, in addition to simple technological know-how and strategy know-how.

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The gassed linear liquid velocities differ from the ungassed velocities because impeller power consumption and pumping capacity of the impeller decrease due to gassing. 0 [37]. 64 has been estimated. The simulations have been performed for the vessel and impeller geometries used by Bombac et al. [38, 39] in their systematic investigations of the distribution of specific gas hold-up at different speeds of agitation. These measurements were performed by using conductivity sensors. For the prediction of the interfacial forces it is necessary to estimate a representative bubble diameter.

Secondly, other important interfacial forces are not considered in the gas phase momentum balance. Neglect of the added mass force especially leads to errors in the simulation of the gas phase, as recognized by Jenne [43] and Friberg [51]. Nevertheless, simulations of gas-liquid flow with the algebraic slip model yield reasonable results. 6%. For these simulations power consumption for the gassed systems was predicted from the empirical correlation for multiple gassed impellers suggested by Cui et al.

An alternative is to consider an increase of the turbulent viscosity in the liquid phase caused by the bubbles. Ac- 33 Integration of Physiology and Fluid Dynamics cording to Sato [34] and Lopez de Bertodano et al. 6. Assuming that the optimized version of the Chen-Kim model is still valid, the transport equations for the turbulence quantities k and e for the two-phase system are given by: n ∂ (r L e L k) ∂ ∂ Ê ∂k ˆ + (r L e L uL, i k) = ∂ x ÁË r L e L s eff ∂ x ˜¯ ∂t ∂ xi i k, s i + and ∂ ∂ xi nt ∂ e L Ê ÁrL k Ë Sct ∂ xi ˆ ˜ + r L e L (Pk – e ) ¯ ∂ (r L e L e ) ∂ ∂ + (r L e L uL, i e ) = ∂ x ∂t ∂ xi i (27) n eff ∂ e ˆ Ê ÁrL eL s ˜ Ë e , CK ∂ xi ¯ ∂ Ê nt ∂ e L ˆ ÁrL e ˜ ∂ xi Ë Sct ∂ xi ¯ Ê e ˆ P P + r L e L Á cl , CK k + c 3, CK K – c 2, CK td tp t d ˜¯ Ë + (28) with Ê ∂ uL, i ∂ uL, j ˆ ∂ uL, i Pk = n t Á + ∂ xi ˜¯ ∂ x j Ë ∂ xj (29) As already discussed in context with the single-phase simulations, boundary conditions at the impeller are predicted from measured data of the averaged velocities.

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