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Download Androgens and Androgen Receptor: Mechanisms, Functions, and by Chung Bon-chu, Hu Meng-Chun (auth.), Chawnshang Chang (eds.) PDF

By Chung Bon-chu, Hu Meng-Chun (auth.), Chawnshang Chang (eds.)

Androgen Receptors is the main finished and recent quantity at the subject, together with discussions of the elemental mechanisms of androgen-androgen receptor activities, their roles within the androgen-related illnesses, and their power medical applications.
Key subject matters coated contain:

-The discovery and cloning of the androgen receptor;
-Androgen receptor coregulators;
-Androgen comparable genes and their consensus DNA reaction parts;
-Basic mechanism of motion together with practical analyses, mobile localization and phosphorylation experiences;
-Cross-talk to different sign transduction structures;
-The fresh connections of androgens to women's ailments, resembling osteoporosis and ovarian cancer.

This e-book is of curiosity to scholars, uncomplicated scientists, and clinicians as either a research consultant and reference of study within the androgen box. it might probably even be used as a sophisticated point textual content in endocrinology, urology, OBGYN, or oncology.

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Extra info for Androgens and Androgen Receptor: Mechanisms, Functions, and Clinical Applications

Sample text

J. Cell Bio!. 1990; 111: 2385 Beato, M. Gene regulation by steroid hormones . , Herrlich, P. and Schutz, G.

1996), suggesting that this repeat may be important for the proper funetioning of the AF-1 domain. a. , 1999), suggesting that the poly-glyeine repeat is not the most important feature of the AF-1 domain . , 2000). , 1999) . It is possible that in the full length AR protein, the AF-1 domain funetions to interaet with eoaetivators and provides an interaetion surfaee for the AR COOH-terminal. , 1995). The DBD of steroid receptors consists of two zinc fingers and is the most highly conserved domain among receptors.

However, the functional consequences of this target specificity have yet to be determined. , 1998). , 1998). , 1998). , 1991). , 1991). Phosphorylation at several residues has been attributed to result in the 112kDa AR. , 1994). , 1998). , 1996). , 2001). Potentially, activation of these signal transduction pathways could enhance AR transcription through direct phosphorylation of AR itself or through phosphorylation of an AR interacting protein such as a coregulator. , 1999). , 2000). Her2 has been reported to enhance AR transcription by both the PB kinase and MAPK pathways.

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