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Download Antibody-Drug Conjugates: Fundamentals, Drug Development, by Kenneth J. Olivier Jr., Sara A. Hurvitz PDF

By Kenneth J. Olivier Jr., Sara A. Hurvitz

Providing sensible and confirmed suggestions for antibody-drug conjugate (ADC) drug discovery luck in oncology, this booklet is helping readers enhance the drug protection and healing efficacy of ADCs to kill exact tumor cells.

• Discusses the fundamentals, drug supply thoughts, pharmacology and toxicology, and regulatory approval strategies
• Covers the behavior and layout of oncology scientific trials and using ADCs for tumor imaging
• Includes case reviews of ADCs in oncology drug development
• Features contributions from highly-regarded specialists at the frontlines of ADC examine and development

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Additional resources for Antibody-Drug Conjugates: Fundamentals, Drug Development, and Clinical Outcomes to Target Cancer

Example text

Trastuzumab and paclitaxel for adjuvant therapy for stage I breast cancer Abbreviations: ASCT, autologous stem cell transplant; CR, complete response; ORR, overall response rate; OS, overall survival; PC, physician’s choice; PFS, progression free survival. Trastuzumab emtansine Results Study design Trial Table 3 (Continued) xxx Historical Perspective: What Makes Antibody–Drug Conjugates Revolutionary? Historical Perspective: What Makes Antibody–Drug Conjugates Revolutionary? ­Why ADCs Are Revolutionary?

Thus, from the perspective of a medicinal chemist, an ADC is a prodrug that can only be activated within tumor cells and is excluded from normal cells by virtue of conjugation to a protein. In addition, giving the in vivo distribution properties of an antibody to the small molecular weight cytotoxic agent has the potential to reduce its systemic toxicity. Antibody-Drug Conjugates: Fundamentals, Drug Development, and Clinical Outcomes to Target Cancer, First Edition. Edited by Kenneth J. Olivier Jr.

1). Furthermore, conjugation of a small molecular weight cytotoxic agent to a large hydrophilic antibody protein is expected to restrict penetration of the cytotoxic compound across cellular membranes of antigen-negative normal cells, providing an additional mechanism by which the therapeutic index of the small molecule cytotoxin is widened, beyond that of targeted delivery. Thus, from the perspective of a medicinal chemist, an ADC is a prodrug that can only be activated within tumor cells and is excluded from normal cells by virtue of conjugation to a protein.

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